Rhein (Rhubarb Extract) 98%
CAS: 478-43-3
Molecular Formula: C??H?O?
Molecular Weight: 284.22
Appearance: Yellow to orange crystalline powder

? Core Value Proposition

Multi-Concentration Flexibility

• ≥98% Pure: Pharmaceutical/Nutraceutical Grade (HPLC-verified)

• 1%-50% Blends: Cost-effective solutions for functional foods and cosmeceuticals

? Clinically Validated Benefits

Anti-Tumor & Chemoprevention:

• Inhibits proliferation of melanoma (76% suppression in murine models), breast cancer, and hepatocellular carcinoma by modulating NF-κB and STAT3 pathways, inducing apoptosis via mitochondrial disruption.
  Antioxidant & Anti-Inflammatory:

• Reduces oxidative stress by scavenging ROS and suppresses COX-2, lowering systemic inflammation and LDL oxidation.
  Metabolic & Renal Health:

• Reverses insulin resistance, lowers serum triglycerides by 18–32% in diabetic models, and protects against diabetic nephropathy via glucose transporter- inhibition.
  Antibacterial Activity:

• Effective against Staphylococcus aureus and P. acnes (MIC: 1.5–25 mg/mL) by inhibiting bacterial DNA synthesis.

?? Technical Specifications

Parameter	Detail
Purity Range	1%, 5%, 10%, 98%+ (HPLC)
Source	Rheum palmatum L. roots
Extraction Solvent	Ethanol (food-grade, GRAS)
Melting Point	321–322°C (sublimes)
Storage	2–8°C, sealed, avoid light (24-month stability)
Heavy Metals	≤10 ppm (USP/EP compliant)
Solubility	Soluble in alkaline solutions, pyridine; insoluble in water 16

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? Industry-Specific Applications

? Pharmaceuticals:

• Cancer Adjuvants: Synergizes with chemotherapy in liver and colorectal cancer regimens.

• Diabetic Nephropathy Therapy: Improves renal function in Type 1/2 diabetes models.
  ? Cosmeceuticals:

• Anti-Acne Formulations: Antibacterial action against P. acnes.

• Anti-Aging Serums: Neutralizes UV-induced free radicals and reduces photoaging.
  ? Energy Technology:

• DSSC Co-Sensitizers: Enhances solar cell efficiency (7.83% vs. baseline 7.13%) by reducing electron recombination in TiO? anodes.

? Competitive Advantages

?? Advanced Extraction & Purification:

• Ultrasound-Assisted Extraction: 92% yield vs. 60% conventional methods.

• Resin Chromatography: Combines HPD-300 macroporous resin with preparative HPLC for >98% purity.
  ? Bioactivity Optimization:

• Ethanol-based process preserves thermolabile anthraquinone antioxidants, avoiding degradation to inactive metabolites .
  ? Certified Quality & Compliance:

• ISO 9001/Kosher/Halal certified. Full dossier support (COA, MSDS, Stability Data). Meets FDA GRAS, EU Novel Food, and APAC safety standards.

? Packaging & Delivery

? FAQ

How to verify Rhein authenticity?
Free samples (20g) with batch-specific COA (HPLC/UV verification at λmax 432nm).

Can I request custom derivatives?
Yes—OEM services for:

• Alkylated Rhein (e.g., C6/C8 chains for DSSC co-sensitizers).

• Mitochondria-Targeted Probes: Triphenylphosphonium conjugates for cancer theranostics.

Critical storage notes?
Degrades ≤15%/month at 25°C; strict 2–8°C storage required to maintain potency.

Why Partner With Us?

? Sustainable Sourcing: Rheum palmatum from GAP-certified farms (Xinjiang, China).
? End-to-End Customization:

• Extraction ratios (1% to 98%), enteric coatings, private labeling.

• Derivatives for targeted drug delivery (e.g., liver cancer mitochondria probes).